你在路上應該沒看過跟你長一模一樣的人吧?👤👤
人類基因不會百分百遺傳,主要是因為人類的 #遺傳多樣性 靠父母染色體的配對跟互換,當🧬DNA互換不完美時就會發生基因變異。其中,DNA互換時負責在旁邊加油添醋,阿不是,是加油打氣的催化酵素叫做 ⭐DMC1⭐
雖然父母染色體的DNA序列很相似,卻不完全相同,但是DMC1卻可以協助不完美的DNA配對並完成完美互換!為什麼DMC1可以做到呢?㊙中研院的秘密武器 #高解析度冷凍電子顯微鏡 最近看穿這一套戲法!
🎯中研院與臺大研究團隊透過冷凍電顯技術,解出 #原子級解析度 的DMC1-DNA複合體結構,看到DMC1蛋白和DNA彼此相互作用時的分子細節。發現在DNA錯誤配對的位置,DMC1藉由結構上較大的空間與支持,允許DNA不完美配對與互換。
此發現未來對於因DMC1突變造成的不孕,及染色體分配不均而導致的疾病,可望提供分子層次上的解釋。
#中研院 #臺灣大學 #生化所 #何孟樵 #蔡明道 #冀宏源 #李弘文 #遺傳 #染色體 #冷凍電顯
________________________________
🔬幫劃重點:沒有這一台,可能就看不到了🔬
高解析度冷凍電子顯微鏡(cryo-EM)是現今結構生物研究最具發展潛力的技術,能在 #原子尺度,快速且不破壞性地觀察生物分子。簡單來說,一般光學顯微鏡頂多百倍,冷凍電顯則能看到十萬倍。
📍還是不懂? https://research.sinica.edu.tw/tsai-ming-daw-cryo-electron-microscope/
📍論文連結:https://www.nature.com/articles/s41467-020-20258-1
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Genetic diversity is a key driving force of evolution. During homologous recombination, chromosomes from father and mother will pair together to exchange the genetic material leading to genetic diversity. In the process of chromosome pairing, the DMC1 protein is the key enzyme that catalyzes the DNA exchange reaction. What puzzles scientists is that although the chromosomal DNA sequences of the father and mother are similar, they are not completely the same. How DMC1 can tolerate the imperfection? What is the underlying mechanism? The research teams from National Taiwan University and Academia Sinica used a newly established cryo-electron microscopy facility and biochemical experiments to show that the DMC1 protein possesses a unique structure to accommodate imperfect pairing. The research results were published in the top-tier journal Nature Communications in January, 2021.
‧Article: https://www.nature.com/articles/s41467-020-20258-1
同時也有10000部Youtube影片,追蹤數超過2,910的網紅コバにゃんチャンネル,也在其Youtube影片中提到,...
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dna recombination 在 葉漢浩 Alex Ip Facebook 的最佳解答
被撤回的文章,英文版如下,please Share to your network.
The English version of Prof Yuen and Prof Lung's article is already available: 👇🏻
18 Mar 2020: David Christopher Lung, Yuen Kwok-yung: Pandemic Originated from Wuhan; Lesson from 17 Years Ago Forsaken
Winter of Jihai (2019), a virus began in Wuhan. Comes spring of Gengzi (2020), an epidemic broke out in Hubei. Within China, there were 80,000 confirmed cases, and 3,000 deaths. People were confined in their homes and the epidemic only began slowing down towards the end of the month, yet the virus had leaked to the world outside before it could be stopped. In March, it was a pandemic, only it was announced too late by the World Health Organization (WHO). Countries lacked measures and reserves, and the pandemic swept across the globe. Singapore, Hong Kong, Macau, and Taiwan were spared from the pandemic with continuous sprinkles of overseas imported cases and small groups, but have not yet fallen.
This pandemic came from a virus, shaped like a corona, hence named Coronavirus. Since 2015, WHO has avoided using names of people, places, animals, food, culture, occupation, etc., to name illnesses. For this one, the “year” was used for differentiation, COVID-19. In the naming of viruses, International Committee on Taxonomy of Viruses (ICTV) analyses only the genome sequencing meticulously and disregards the other aspects. Since the genome sequence of this Coronavirus was “not novel enough”, it belongs in the same sisterhood with the SARS Coronavirus, also known as SARS 2.0 (SARS-CoV-2). Local and international media call it the Wuhan Coronavirus or Wuhan Pneumonia, simple and straight-forward, which is not incorrect.
Much controversy has resulted in society regarding the name of this pandemic. In fact, the illness was named by WHO, while the virus was named by ICTV. Nicknames are conventional, as long as they are clear and understood. In scientific discussions or academic exchanges, COVID-19 or SARS-CoV-2 must be used. In daily public communications or media wordings, Wuhan Coronavirus or Wuhan Pneumonia are both conventional, easy to understand, and great for communication purposes.
The Pandemic of Gengzi, an Origin in Wuhan
Around 75% of the newly discovered infectious diseases originated from wild animals. Among the few that could infect mammals is the Coronavirus, whose ancestral virus originated from bats or avians. Both have the ability to fly thousands of miles to the place the virus was first discovered, therefore the naming of a virus would also include its place of origin. To investigate the origin of a virus, the correct and objective way is to isolate the virus from the animal host. Unfortunately, since Huanan Seafood Wholesale Market was eradicated early on, the wild animals in the market were already gone by the time researchers had arrived to collect samples. The identities of the natural host and the intermediate host became a mystery. According to the locals, the wild animals sold within the Market came from all over China, Southeast Asia, and Africa (smuggled) to be distributed from there. The ancestral virus of the Wuhan Coronavirus cannot be determined.
Using genome sequencing to determine its origin, a bat Coronavirus stand (RaTG13) was found to be extremely similar to the Wuhan Coronavirus, with a sequencing similarity of 96%, therefore it is believed to be the ancestral virus stand of this Wuhan Coronavirus. This particular virus strand was obtained and isolated from Yunnan bats (Rhinolophus sinicus), and bats are believed to be the natural host of this Wuhan Coronavirus. Epidemiology clearly indicated Huanan Seafood Wholesale Market as the amplification epicenter, where there was a huge possibility that the virus had cross-infected between the natural host and the intermediate host, and then mutated within the intermediate host to adapt to the human body, followed by human-to-human infections.
The identity of the intermediate host remains unknown, but genome sequencing indicated that the Spike Receptor-binding domain of the Wuhan Coronavirus has a 90% similarity to that of the pangolin Coronavirus strand. Although the pangolin could not be confirmed as the intermediate host, it is highly possible that this pangolin Coronavirus strand donated Spike Receptor-binding domain DNA (or even the entire sequence) to the bat Coronavirus strand. Though gene shuffling recombination, the novel Coronavirus was born.
Wild Animal Market, the Origin of Innumerable Viruses
The 2003 SARS virus originated from Heyuan, became an epidemic in Guangdong, and passed to Hong Kong. The SARS Coronavirus was found in civets, and China clearly banned the trading of wild animals afterward. 17 years on, the wild animal market has run amuck. The Chinese have outright forgotten the lessons from SARS and have allowed a live wild animal market to exist within the centre of a highly developed city, with wild animals being cooked and eaten in brought daylight – simply astonishing. The feces of the animals within a live wild animal market contain a large amount of germs and viruses. With a crowded environment, vile hygiene, and a mix of wild animal species, gene shuffling and mutation could easily occur in viruses, therefore these markets must be banned.
Reform of the wet markets should be a focus of epidemic prevention. The mainland Chinese and Hong Kong governments must quickly improve these environments by enhancing ventilation and pest control. Before the complete elimination of live-animal markets, animal feces must be well handled to minimise the chances of gene shuffling in viruses.
The online rumour that the virus originated from USA was absolutely groundless, delusional. Stop spreading the falsity before we expose ourselves to ridicule. To remain calm before a pandemic, informational transparency is of the utmost importance. With calm and objective analysis, refrain from parroting others and spreading hearsay. Not strictly enforcing the closure of all wild animal markets after SARS was a grave mistake. In order to defeat an illness, one must own up to the mistakes and face the truths. Stop committing the same mistakes and putting the blame onto others. The Wuhan Coronavirus was a product of the inferior culture of the Chinese people: excessive hunting and ingesting wild animals, inhumane treatment of animals, disrespecting lives. Continuing to devour wild animals for human desires, the deep-rooted bad habits of the Chinese people are the real origin of the virus. With this attitude, in a dozen years, SARS 3.0 is bound to happen.
(Dr Lung graduated in 2004 from the University of Hong Kong, Faculty of Medicine with distinction in Medicine. He currently works in the Hong Kong Children’s Hospital, where he built up the microbiology team and lab. Yuen Kwok-yung is a Professor and Chair of Infectious Diseases of the Department of Microbiology of the University of Hong Kong)
(Original image by Ming Pao)
https://news.mingpao.com/pns/%e8%a7%80%e9%bb%9e/article/20200318/s00012/1584470310596/%e9%be%8d%e6%8c%af%e9%82%a6-%e8%a2%81%e5%9c%8b%e5%8b%87-%e5%a4%a7%e6%b5%81%e8%a1%8c%e7%b7%a3%e8%b5%b7%e6%ad%a6%e6%bc%a2-%e5%8d%81%e4%b8%83%e5%b9%b4%e6%95%99%e8%a8%93%e7%9b%a1%e5%bf%98
dna recombination 在 辣媽英文天后 林俐 Carol Facebook 的最讚貼文
感謝鄧學長接受俐媽的邀稿,貢獻出「生物技術餐」&「醫學檢驗餐」。
實在太豐富了👏🏻👏🏻👏🏻!
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🔬 鄧哥+俐媽英文教室—生物技術篇:
🧬 forensic science 鑑識科學
🧬 DNA fingerprint DNA指紋辨識
🧬 PCR = polymerase chain reaction 聚合酶連鎖反應
🧬 Microarray DNA微陣列
🧬 genetic engineering 基因工程
🧬 haploid 單倍體
🧬 diploid 雙倍體
🧬 Allopolyploidy 異源多倍體
🧬 Polyploid = Autopolyploidy 同源多倍體
🧬 external fertilization 體外受精
🧬 induce (v.) 誘變
🧬 cloning (n.) 克隆;複製
🧬 chromosomes 染色體
🧬 gametes 配子
🧬 conjugation接合
🧬 budding 出芽生殖
🧬 Vegetative propagation 營養器官繁殖
🧬 fission 分裂生殖
🧬 spore formation= spore generation孢子繁殖
🧬 fragmentation 斷裂生殖
🧬 parthenogenesis 單性生殖
🧬 sexual reproduction 有性生殖
🧬 asexual reproduction 無性生殖
🧬 genetic recombination 基因重組
🧬 meiosis 減數分裂
🧬 mitosis 有絲分裂
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🔎 鄧哥+俐媽英文教室—醫學檢驗篇:
🧪 lab = laboratory 實驗室
🧪 medical laboratory scientist 醫檢師
🧪 chemical testing section 化學檢驗
🧪 preventive medicine 預防醫學
🧪 blood test 血液檢查
🧪 microscope 顯微鏡
🧪 biochemistry 生化
🧪 immunology 免疫學
🧪 microbiology 微生物學
🧪 cytology 細胞學
🧪 ECG = EKG = Electrocardiography 心電圖
🧪 pathology 病理學
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有相關領域的孩子,歡迎補充!
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#俐媽英文教室 #俐媽英文教室醫學檢驗篇 #俐媽英文教室生物科技篇
dna recombination 在 コバにゃんチャンネル Youtube 的最佳貼文
dna recombination 在 大象中醫 Youtube 的最佳貼文
dna recombination 在 大象中醫 Youtube 的最佳解答
dna recombination 在 DNA recombination - Latest research and news | Nature 的相關結果
DNA recombination is the exchange of DNA strands to produce new nucleotide sequence arrangements. Recombination occurs typically, though not exclusively, ... ... <看更多>
dna recombination 在 recombinant DNA | Definition, Steps, Examples, & Invention 的相關結果
Recombinant DNA, molecules of DNA from two different species that are inserted into a host organism to produce new genetic combinations that are of value to ... ... <看更多>
dna recombination 在 Genetic recombination - Wikipedia 的相關結果
Genetic recombination is the exchange of genetic material between different organisms which leads to production of offspring with combinations of traits ... ... <看更多>